Articles Tagged With:
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Repeated Head Impacts Are Associated with Tau Astrogliopathy
This study demonstrates that both traumatic brain injury and participation in contact sports are independently associated with increased tau astrogliopathy, particularly thorn-shaped astrocytes, even when cases of chronic traumatic encephalopathy neuropathologic change are excluded.
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Intracranial EEG Activity and Consciousness in Frontal Lobe Seizures
Frontal seizures were classified as focal preserved consciousness (FPC), focal impaired consciousness (FIC), or focal to bilateral tonic-clonic (FBTC). Intracranial electroencephalogram (icEEG) recording was analyzed in those seizures. FPC seizures showed significant icEEG power increases in the seizure-onset region across frequency ranges, with smaller increases in other regions. FIC seizures demonstrated a significant increase in icEEG power not only within the seizure-onset zone but also across distal cortical regions. Widespread power increases also were noted in FBTC seizures. In addition, the power increase in FBTC is much greater compared to FIC seizures.
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Increased Treatment Opportunities for Trigeminal Autonomic Cephalalgias
Trigeminal autonomic cephalalgias (TACs) include cluster headache, paroxysmal hemicrania, hemicrania continua, short-lasting unilateral neuralgiform headache with conjunctival injection and tearing, and short-lasting unilateral neuralgiform headache with cranial autonomic symptoms. They are female-predominant primary headache disorders that coexist with migraines and mood disorders. Indomethacin is underused in those TACs that are specifically indomethacin responsive. Noninvasive vagus nerve stimulation for TACs is well-tolerated and more effective for prevention than as an acute treatment.
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Oral Health for the PCP: A Collaborative Approach to Patient Care
Primary care physicians play a critical role in recognizing oral health as a sign of systemic disease. Common oral conditions can have diagnostic and preventive implications for broader health, including cardiovascular disease and autoimmune disorders. By conducting oral examinations, identifying red flags that require referral, and counseling patients on preventive care, physicians can integrate oral health awareness into comprehensive patient care.
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Infectious Disease Updates
Visceral Larva Migrans from Baylisascariasis; Measles Testing of Persons with HIV; Ambulatory Glucose Monitoring a Risk for Bloodborne Pathogens
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Fleas, Typhus, and Texas
Cases of flea-borne typhus are dramatically increasing in Texas.
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Pertussis: Concerning News from Mexico, Brazil, and China
Related to under-immunization of pregnant women and children, pertussis is spreading in several countries within the Americas. Macrolide resistance of Bordetella pertussis is now common in China.
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Meningococcal Conjunctivitis in Military Trainees
Forty-one cases of conjunctivitis due to Neisseria meningitidis occurred in vaccinated military trainees over several months at a Texas facility. Topical treatment alone was successful, and no cases developed invasive infection due to this unencapsulated strain.
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Computerized Order Entry Reduces Antibiotic Use in Low-Risk Patients Hospitalized with SSTIs
A cluster randomized clinical trial assessed the effect of an antibiotic stewardship bundle that included computerized provider order entry (CPOE) prompts vs. routine stewardship on antibiotic selection during the first three hospital days in noncritically ill adults hospitalized with skin and soft tissue infections. CPOE prompts significantly reduced use of extended-spectrum antibiotics without increasing admissions to intensive care units or hospital length of stay.
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Preventing SARS-CoV-2 Infection with an Allergy Nasal Spray
Use of the antihistamine azelastine nasal spray was effective in preventing SARS-CoV-2 infection in young, healthy, vaccinated outpatients.